Should I wake my puppy up to pee at night?

Young pups under 4-6 months old must urinate significantly more frequently than an adult dog because of their immature bladders. Puppies in their early stages should relieve themselves 10 to 15 minutes after eating or drinking. Depending on how many months old your puppy is, you must take them outside for a pee-pee cycle frequently, at least every hour or two.